Sportsmail understands there are fears De Bruyne has torn a lateral ligament in his right knee and City are anxious their playmaker could miss up to three months.
They then face matches away to Wolves and at home to Newcastle before an global break.
It is billed as a behind-the-scenes look at City's incredible Premier League title triumph as they became the first team to reach 100 points on their way to lifting the trophy.
In the first of eight episodes, viewers witnessed in-depth interviews with Guardiola, Sergio Aguero and Kevin de Bruyne, who arrived to the screening on crutches after injuring his knee in training.
It remains to be seen just how serious the 27-year-old's injury is, but Opta data shows he will be sorely missed if he ends up on the sidelines for a significant period of time.
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'It is unlucky for Kevin - the season has only just begun and it's always good to be back but as long as his ligaments are not torn we can remain hopeful he'll make a quick recovery'.
Pep Guardiola's side were beaten 5-1 on aggregate by Premier League rivals Liverpool in the quarter-finals of the Champions League, but De Bruyne believes that the top-flight title requires more consistency to win. "Obviously it's a big loss but we've got more than enough cover".
"He had so much impact on our game".
Manchester City's behind-the-scenes, club-approved documentary will fan the flames of the rivalry between Pep Guardiola and Jose Mourinho, portraying the Manchester United manager as a defensive-minded negative coach during last season.
"When you do well, you train hard, you work hard, you get more leadership on the field".