The Dow Jones Industrial Average sank 137.65 points, or 0.5 percent, to 25,986.92.
Looking at the weekly performance, both the Dow and the S&P 500 are on track for their third straight weekly gain, while the Nasdaq is poised for its second straight positive week.
Trade talks between Canada and the United States had yet to clear some remaining hurdles as negotiators struggled to meet a Friday deadline.
US stocks opened lower on Friday for a second day in a row, as concerns about the ongoing trade talks between the United States and other major economies hampered a record rally for the major indexes. "Freeland told reporters that Mexico's "difficult" concessions to the States earlier this week would help lead the way for productive discussions between the three countries this week", adds the article. The S&P 500 index was up 1.73 points at 2,902.86, while the Nasdaq composite was up 22.89 points at 8,111.26.
Canada's main stock market fell Thursday due to unresolved NAFTA talks.
The S&P financial index (.SPSY) fell 0.25 percent with JPMorgan (JPM.N) down 0.8 percent, Goldman Sachs (GS.N) off 0.2 percent and Citigroup (C.N) which dropped 0.7 percent.
Barcelona 8-2 Huesca: Lionel Messi-inspired champions thrash minnows
Suarez won an injury-time penalty following a foul by keeper Axel Werner and threw the ball to Messi so he could score his third. Huesca were not done there, though, as Alex Gallar netted a second for the visitors just before the half-time interval.
Eagles expected to start Nick Foles in opener
The 23-year-old played in the Eagles' preseason game Thursday against the Jets, completing 7 of 16 passes for 69 yards. Wentz has made significant progress in his offseason rehab, but will not be available for Philadelphia's season opener.
Bono suffers ‘complete loss of voice’, U2 cancels show
The audience waited to see if the band would resume the concert after taking a break of about 15 minutes. The band released the following statement: "We're so sorry for tonight's cancellation.
The Russell 2000 picked up 15.08 points, or 0.9 percent.
The Dow gained 174.47 points, or 0.7 percent.
The S&P 500 is up 227.52 points, or 8.5 percent.
Apple (AAPL.O) rose 1.6 percent, extending its gains for the seventh day. Its shares dipped 1.1 percent.
Declining issues outnumbered advancing ones on the NYSE by a 1.22-to-1 ratio; on Nasdaq, a 1.26-to-1 ratio favored advancers.