Chelsea's Barkley scored his first goal for Maurizio Sarri's unbeaten Chelsea to help move them provisionally top of the Premier League in the 3-0 shutout at St Mary's.
"That (tiredness) is in the mix I suppose but you could also throw in the confidence they have got from their home form", he said. I don't play against the manager, we play against Liverpool.
Only one of their league games has been a real contest - the away match at Wolves - and City only failed to win there due to a refereeing error.
It would also go some ways to making amends for the woeful defeat to Livingston last weekend which saw his team fall to yet another defeat, in which he was hooked early on in the second half and replaced by Glenn Middleton.
Asked if people saying Liverpool had worked out how to beat City were correct, Guardiola said: "Good - congratulations". That's what you have to do in games like this.
Sure, it may all change in the next four or five games, but something tells me the top five or six will remain tightly bunched until December, at least.
It was a similar story for City in the Premier League encounter at the same ground in January, when three goals in nine second-half minutes proved their downfall in a 4-3 loss. If we don't entertain the people why are we playing then? At the end, it's the teams and the clubs that win the game.
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"We just got it wrong", said frustrated Hearts boss Levein when quizzed about his side's defending for the first goal.
Napoli's pressing didn't allow the front three any time on the ball and they should expect much of the same against City, so they'll have to get rid of the ball much quicker and play more of those little passing triangles they manage to pull off so well.
Klopp has been described as Pep Guardiola's nemesis but the German insisted there is no magic formula to beating City.
"You have to be ready, you need a fantastic football team - which thank God I have - with outstanding character, ready to be really fearless, ready to make mistakes".
Alisson has had a good start and barring that mishap against Leicester City, he has put in consistent performances. We don't know in this moment as well if he can train tomorrow, we have to see.
"So yeah there's similarities but Alfredo is a young lad who's still learning and growing so I think it's a bit unfair to compare him to Suarez".
"It's not always possible and it's always hard work but that's really an important thing".