While the 25-year-old has scored four goals in two games for Belgium in the Nations League he has needed 13 in all competitions to reach that tally for United.
"One day will be and one day he will score and one day his confidence levels will be back to normal, which clearly they are not there but I always feel that."
Sanchez is not the only senior figure now unavailable to Mourinho, with the United boss having once again hit out at worldwide sides for failing to look after his players.
"So against Juventus or we play with the players that we did or we decide to give a rest to Lukaku, then Rashford, who plays as a winger?"
"He's got to keep playing him".
While Luke Shaw and Nemanja Matic both returned early and were able to play against Chelsea and Juventus, Sanchez, Marouane Fellaini, Diogo Dalot and Scott McTominay missed both games despite remaining with their countries for the full two-week break.
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"All of them national team", the United boss said.
"Because numerous players they belong to these top teams, so we work with what we have we try to improve with what we have".
He played no part in a Champions League defeat to Juventus and, as questions continue to be asked of his working relationship with his manager and future in Manchester, the 29-year-old will also sit out a Premier League home date with Everton on Sunday.
Ibrahimovic has done well in Major League Soccer, but Mourinho dismissed talk of the veteran returning on loan.
Mourinho has backed Romelu Lukaku to come good despite the Belgian striker going eight games without scoring.
"So now he's going back to do the work to try and be 100 per cent".