Anthony Martial pulled one back for United from the penalty spot after Ederson fouled Romelu Lukaku in the box. However, they have improved of late, and are unbeaten in five league games.
Former United defender Neville said he does not blame Mourinho for the result, especially as only two of the players starting against City were his signings.
"I'm not going to be so quick to sit here and say it is the coaching staff's fault - there is a problem structurally at this club which means it would be hard for any coach to get this team to perform".
"He felt that was such a crucial match for the team".
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And any doubts about Bryant fitting into the locker room were addressed as well. "They're my family", Bryant said. Dez Bryant wasn't about to declare himself a changed man just because he'd changed teams.
"One team [City] started the season strong and are still strong, another team [United] didn't start well and is improving a lot", he added. "I think they will". They had 6-0 wins, no pressure, relaxed. Mourinho's team have kept just one clean sheet in the league this season and David Silva's strike in the 12th minute was the seventh time in 12 games that they have conceded first and the sixth time in nine they have conceded inside the first 20 minutes.
"So, when I analyse the game - you can go for stats, that's the way people who don't understand football analyse, with stats - I don't go for stats".
GK David De Gea, 6 - The Spanish worldwide conceded from City's first two shots on target and will be unhappy to have been beaten at his near post by Aguero, though but there was a lot of power behind the effort. We were punished, but the performance, mentality, togetherness, belief, fighting until the end, is something we are building.
"We can not lose the ball the way we did".