Australian Nick Kyrgios takes on 16th seed Milos Raonic in arguably the biggest first-round match-up in the men's draw.
Aiming for a 21st Grand Slam trophy and a 100th career singles title, Federer will open against Denis Istomin.
Serb Djokovic could then face a rematch of his 2008 final triumph over Frenchman Jo-Wilfried Tsonga in the second round, before a possible second week match-up against Japan's Kei Nishikori in the quarter-finals.
Cilic was drawn into the same section as five-time finalist Andy Murray, who is coming back from a long-term hip injury and is set to open against No. 22-seeded Roberto Bautista Agut.
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As I said I am a little from the black side (influenced by West Indies culture) so I have to see how they (women) move first". On the show, Pandya bragged about having affairs with multiple women and even spoke about being candid about it with parents.
Those two, and seventh seed Dominic Thiem, are in the same quarter as Alexander Zverev, who could meet Djokovic in the semi-finals but must first plot his way past Aljaz Bedene in the opening round.
Kyle Edmund, back at the scene of his semi-final appearance 12 months ago, was also given a hard opener at the year's first grand slam against former top-10 stalwart Tomas Berdych, who is unseeded following injury.
In the women's tournament, Serena Williams's bid for a record-equaling 24th Grand Slam title and eighth at Melbourne Park will kick off against German world No. 71 Tatjana Maria.
Unseeded Estonian Kanepi knocked Halep out of the first round at Flushing Meadows previous year, making the Romanian the first top seed to lose at that tournament's earliest stage.
"I can't believe it's been a year already", Dane Wozniacki said at the draw ceremony.