United were 11 points adrift of the Champions League places when Ole Gunnar Solskjaer took over in December but the 3-0 win over Fulham on Saturday lifted them into the top four for the first time since August.
A win for United would see them over take fourth-placed Chelsea, and with the Blues travelling to title-chasing Manchester City on Sunday, there is no guarantee of a response.
"You've got to trust the players, because the league is vital for us but it's a chance for them to say "I should play on Tuesday".
Discussing his decision to change his line-up, which including leaving Marcus Rashford on the bench after he picked up a knock at Leicester, Solskjaer said: "If we are going to be successful this season, we need everyone to contribute and everyone in the squad knows they've got chance to contribute if it's now or next week or the week after. I speak to him like I do with the others, that's management". Pogba is the captain in everything but name, the leader in the dressing room and on the pitch. The last-ditch, winning games at the end, winning points at the end, that was fantastic.
"I've been in that situation a few times myself and it's about who grabs it".
"It's not me making a difference to the club".
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So when you lose you get at least three letters. "We play strong off set-piece, we play a varied kicking game, we play with a varied attacking game".
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Guardiola said this was because De Bruyne is still being eased back following injury: "It's quite possible [he might not start]". In Mendy's absence, City reclaimed top spot on the Premier League in midweek with a 2-0 victory over Everton at Goodison Park.
"But I think now is not the time to think about individuals but to think about the great moment that we are enjoying as a team". "We've done really well in the 11 games we've played, but that's down to the team effort", he said.
Fulham fans made their feelings clear as they booed Schurrle when he was replaced by Cyrus Christie on 53 minutes and applauded the decision to take off Ryan Babel on 77 minutes after the Netherlands global had hit the post from point blank range.
"But my players are very. not anxious, but they want to score immediately, but against big teams, it's hard. That's the real problem".
Appointed a month before Solskjaer, the Italian was subjected to chants of "you don't know what you're doing" early in the second half by the irked Craven Cottage faithful.
Since the start of season in Premier League and Champions League, Pogba has 12 goals and 10 assists, which is a hand in 22 goals, just one short of his personal best.