Serena Williams' return to tennis after a five-week break ended early with her retiring from the BNP Paribas Open because of a viral illness Sunday.
After a first set in which she had led 3-0, Williams had a lengthy conversation with the trainer and doctor but no medical timeout was taken.
"I wish I'm going to see her soon and feeling better", added the Spaniard, who advanced to a fourth-round clash with seventh-seeded Kiki Bertens of the Netherlands, a 7-6 (12/10), 6-4 victor over Britain's Johanna Konta.
Williams was suffering from a viral infection, according to tournament officials, which was later confirmed by Williams herself.
"By the score, it might have looked like I started well, but I was not feeling at all well physically", Williams said.
"When I was leading the match, she played without fear, I felt like she was playing much better in those games", Halep said.
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Nadal thrashed Jared Donaldson 6-1 6-1 and Federer beat Peter Gojowczyk 6-1 7-5.
There were service breaks aplenty as Halep and Kozlova traded four on the way to the first-set tiebreaker and four more to open the second set.
She retired after losing the first game. That year she reached the semifinals before withdrawing against Simona Halep. One long backhand miscue by Williams sealed the first set for Muguruza after a promising start by the American.
She quickly called time on proceedings, handing Muguruza a place in the last 16 - where she will meet Kiki Bertens or Johanna Konta.
"If someone would have told me I would have gone to the third round of this tournament at the beginning of the year, I would have said, 'You're crazy,"' Andreescu said.
Along with Williams, the other seed to depart was Elise Mertens, the Belgian beaten by Wang Qiang 7-6 (7-4) 6-7 (4-7) 6-3 after a three-hour battle.