With the United Kingdom about to leave the bloc on March 29, possibly without an exit deal, that poses a problem for certain large airlines with a major British presence, in particular Ryanair and EasyJet.
Speaking in a joint press conference, Mr Juncker insisted that if the deal is not accepted by Parliament, then "Brexit may not happen at all". In that case, Britain and the EU's trade would go back to the World Trade Organization's default rules governing all trade, without special agreements. "Threatening no deal helps with leverage with the European Union, but it hasn't really achieved much".
May's office says talks are continuing to try to secure changes to the deal that can win over opponents in Parliament.
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Sterling climbed as much as 1.1 percent after gaining 1 percent on Monday amid optimism that progress is finally being made to resolve the Brexit standoff.
A plane was reported to be on standby at RAF Northolt to fly her to Brussels to clinch an agreement if there was any sign of a deal emerging from talks over the weekend between officials.
"The choice is clear", he said.
The deadlocked talks effectively open up the prospect of either a last-minute deal, probably around the time of an European Union summit on March 21-22, or a delay to Brexit.
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For pro-Brexit campaigners, that would be a betrayal of the 2016 referendum vote to leave the EU.
After they sort out the terms of withdrawal, they will have to negotiate a new free-trade agreement, which typically takes years - and which analysts say will be even more hard than what we've been witnessing. However, British citizens would have the right to have a say on who represents them at the EU Parliament while the United Kingdom is still part of the EU.
"It is now for the House of Commons to take an important set of decisions this week", Schinas said. "Benjamin Franklin said of the US Constitution, "I vote for this with all its faults" and I think that's the approach that we need to take on Tuesday, " Hancock told Sky News.
The EU will not budge on the backstop, and that means either Parliament will have to accept the previous agreement with the EU, vote for a no-deal exit, or delay Brexit for more negotiations.
If the MPs agree to extend Article 50 and therefore the negotiation process, the talks will be extended for a period of time subject to agreement with the EU.
One of the biggest sticking points in January was the so-called "backstop" to avoid a hard border between Northern Ireland and the Republic of Ireland in the event of a no-deal Brexit.
However, according to a timetable pledged by Theresa May last month, if the latest vote on her Brexit agreement fails to go her way, then the Commons will get a chance to vote on leaving the European Union without a deal - a scenario which has very little support within the UK Parliament.